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SM 324405 is a potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma).
| Molecular Weight | 385.42 |
| Formula | C19H23N5O4 |
| CAS Number | 677773-91-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 38.54 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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