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Saquinavir Mesylate

Cat. No. M5949
Saquinavir Mesylate Structure
Synonym:

Ro 31-8959/003

Size Price Availability
10mg USD 54  USD60 Out of stock
50mg USD 225  USD250 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 766.95
Formula C39H54N6O8S
CAS Number 149845-06-7
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation.
Hosny KM, et al. Int J Pharm. 2014 Nov 20;475(1-2):191-7. PMID: 25178831.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Saquinavir Mesylate, Ro 31-8959/003 supplier, HIV Protease, inhibitors

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