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Salicylamide

Cat. No. M20567
Salicylamide Structure
Synonym:

o-hydroxybenzamide

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Quality Control & Documentation
Biological Activity

Salicylamide is a non-prescription drug with analgesic and antipyretic properties.

Chemical Information
Molecular Weight 137.14
Formula C7H7NO2
CAS Number 65-45-2
Solubility (25°C) DMSO 27 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alejandro Torregrosa-Chinillach, et al. Molecules. Asymmetric Conjugate Addition of Ketones to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide

[2] H HOFMANN, et al. Dtsch Gesundheitsw. [Salicylamide]

[3] R REIPERT. Dtsch Med Wochenschr. [Salicylamide]

[4] No authors listed. Lancet. SALICYLAMIDE

[5] F HOLTZ, et al. Schweiz Med Wochenschr. [Salicylamide]

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Keywords: Salicylamide, o-hydroxybenzamide supplier, Immunology/Inflammation, inhibitors, activators


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