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For the development of PSMA ligands, the structurally unrelated PSMA inhibitor 2-(phosphonomethyl)pentanedioic acid (PMPA) is commonly used as a competitor in blocking studies to demonstrate the specific binding of the molecule of interest. In this respect, simultaneous coinjection of a 50 mg/kg dose of PMPA resulted in complete blocking of MIP1095 binding sites in tumor and kidneys
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Mice bearing LNCaP tumors |
| Formulation | HEPES buffered saline |
| Dosages | 50, 10, 1, or 0.2 mg/kg |
| Administration | i.p. |
| Molecular Weight | 287.21 |
| Formula | C9H14N5O4P |
| CAS Number | 147127-19-3 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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