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Rifamycin sodium

Cat. No. M9589
Rifamycin sodium Structure
Synonym:

Rifamycin sodium salt

Size Price Availability Quantity
50mg USD 55  USD55 In stock
100mg USD 83  USD83 In stock
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Quality Control & Documentation
Biological Activity

Rifamycin sodium belongs to the family of ansamycin antibiotics, it is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase.

Chemical Information
Molecular Weight 719.75
Formula C37H46NNaO12
CAS Number 14897-39-3
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hamed Mosaei, et al. EcoSal Plus. Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like Molecules

[2] Heinz G Floss, et al. Chem Rev. Rifamycin-mode of Action, Resistance, and Biosynthesis

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