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RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.
| Molecular Weight | 391.46 |
| CAS Number | 2351843-48-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Miriam Molina-Arcas, et al. Drugging the Undruggable: Advances on RAS Targeting in Cancer
[2] Dirk Kessler, et al. Drugging all RAS isoforms with one pocket
[3] Britney N Wilson, et al. Neurofibromatosis type 1: New developments in genetics and treatment
[4] Amanda R Moore, et al. RAS-targeted therapies: is the undruggable drugged?
[5] Ufuk Degirmenci, et al. Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
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