PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 93 mg/mL|
|Related Phosphatase Products|
|L-Ascorbic Acid 2-phosphate (magnesium salt hydrate)
L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) is a long-term vitamin C derivative that can stimulate the expression and formation of collagen. L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) can be used as a medium to supplement osteogenic differentiation of human adipose stem cells (hASCs). Increased alkaline phosphatase (ALP) activity and runx2A expression in hASC during osteoblast differentiation.
MSI-1436 is a non-competitive inhibitor of PTP1B with a selective IC50 of 1 μM and an IC50 value of 224 μM for TCPTP.
|Etidronic acid disodium
Etidronate disodium (Etidronate disodium; HEDPA disodium; HEDP disodium) is a nonamino bisphosphonate with protein tyrosine phosphatase (PTP) inhibitory activity.
L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.
|Menadione bisulfite sodium
Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
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