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PHPS1

Cat. No. M20829
PHPS1 Structure
Synonym:

PTP Inhibitor V

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 465.44
Formula C21H15N5O6S
CAS Number 314291-83-3
Purity >99%
Solubility DMSO 93 mg/mL
Storage at -20°C
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Keywords: PHPS1, PTP Inhibitor V supplier, Phosphatase, inhibitors

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