Free shipping on all orders over $ 500

P-gp inhibitor 14

Cat. No. M42231
P-gp inhibitor 14 Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

P-gp inhibitor 14 is a high affinity P-gp inhibitor.

Chemical Information
Molecular Weight 638.71
Formula C37H38N2O8
CAS Number 2892571-47-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Naomi Gronich et al. Clin Pharmacol Ther. Association Between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study

[2] Danuta Szkutnik-Fiedler. Pharmaceutics. Pharmacokinetics, Pharmacodynamics and Drug-Drug Interactions of New Anti-Migraine Drugs-Lasmiditan, Gepants, and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies

[3] Yoko Nagai et al. Xenobiotica. Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys

[4] Ankit Saneja et al. Curr Cancer Drug Targets. Co-formulation of P-glycoprotein Substrate and Inhibitor in Nanocarriers: An Emerging Strategy for Cancer Chemotherapy

[5] Hongming Liu et al. Xenobiotica. P-glycoprotein (P-gp)-mediated efflux limits intestinal absorption of the Hsp90 inhibitor SNX-2112 in rats

Related P-glycoprotein Products
Reversin 121

Reversin 121 is a P-glycoprotein inhibitor.
Reversin 205

Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor.
P-gb-IN-1

P-gb-IN-1 inhibitor.
P-gp inhibitor 13

P-gp inhibitor 13 is a P-gp inhibitor.
ABCB1-IN-1

ABCB1-IN-1 is a potent ABCB1 inhibitor.
  Catalog
Abmole Inhibitor Catalog




Keywords: P-gp inhibitor 14 supplier, P-glycoprotein, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.