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NYX-2925 

Cat. No. M29106

All AbMole products are for research use only, cannot be used for human consumption.

NYX-2925  Structure

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Quality Control & Documentation
Biological Activity

NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders.

Chemical Information
Molecular Weight 297.35
Formula C14H23N3O4
CAS Number 2012536-16-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Gladys Morrison, et al. Neurobiol Pain. The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC

[2] M Scott Bowers, et al. J Neurochem. NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

[3] David R Houck, et al. Clin Transl Sci. NYX-2925, A Novel N-methyl-D-aspartate Receptor Modulator: A First-in-Human, Randomized, Double-blind Study of Safety and Pharmacokinetics in Adults

[4] Nayereh Ghoreishi-Haack, et al. J Pharmacol Exp Ther. NYX-2925 Is a Novel N-Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain

[5] M Amin Khan, et al. Int J Neuropsychopharmacol. NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory

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  Catalog
Abmole Inhibitor Catalog




Keywords: NYX-2925  supplier, GluR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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