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NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation.
| Molecular Weight | 438.43 |
| Formula | C20H10N2O6S2 |
| CAS Number | 909197-38-2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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