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NRD-21 is an allosteric inhibitor of PAR1 Gq signaling, with IC50 of 0.38 uM in intracellular calcium mobilization assay. NRD-21 has improved anti-Inflammatory activity and is much more plasma stable than ML161, it is a promising lead compound for the parmodulin class for anti-thrombotic and anti-inflammatory indications research. NRD-21 is highly efficacious in the inhibition of TNF-α-mediated TF expression in endothelium, making it a promising lead within this new class of parmodulin anti-inflammatory agents.
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PAR Products |
|---|
| SCH79797 dihydrochloride
SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. |
| TRAP-6 amide
TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide. |
| Protease-Activated Receptor-1, PAR-1 Agonist
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. |
| FSLLRY-NH2
FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor. |
| iso-TRAP-6
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. |
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Products are for research use only. Not for human use. We do not sell to patients.
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