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Nelfinavir Mesylate

Cat. No. M3654
Nelfinavir Mesylate Structure
Synonym:

AG-1343

Size Price Availability
10mM*1mL USD 79.2  USD88 Custom Synthesis
5mg USD 54  USD60 Custom Synthesis
10mg USD 81  USD90 Custom Synthesis
50mg USD 216  USD240 Custom Synthesis
100mg USD 396  USD440 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nelfinavir Mesylate (also known as AG1343) is a potent enzyme inhibitor (Ki = 2 nM) and antiviral agent (HIV-1 ED50 = 14 nM). Nelfinavir (AG1343) is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. AG1343 (Viracept) has recently been approved for marketing for the treatment of AIDS.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 663.89
Formula C33H49N3O7S2
CAS Number 159989-65-8
Purity >98%
Solubility DMSO: ≥ 20 mg/mL
Storage at -20°C
References

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.
Kaldor SW, et al. J Med Chem. 1997 Nov 21;40(24):3979-85. PMID: 9397180.

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Keywords: Nelfinavir Mesylate, AG-1343 supplier, HIV Protease, inhibitors

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