NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research.
| Molecular Weight | 439.57 |
| Formula | C24H29N3O3S |
| CAS Number | 1120332-55-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related HMGB1 Products |
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| HBP08
HBP08 is a high mobility group protein B1 (HMGB1) modulator that can be used in studies related to inflammation. |
| 18-mer-HP
18-mer-HP is a high mobility group protein B1 (HMGB1) modulator that can be used in studies related to acute liver failure. |
| AFX-2101
AFX-2101 is a high mobility group protein B1 (HMGB1) modulator for studies related to CNS trauma. |
| SB1703
SB1703 is a high mobility group protein B1 (HMGB1) modulator for melanoma-related studies. |
| SB17170
SB17170 is an HMGB1 modulator that can be used in studies related to solid tumors. |
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