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NecroX-7 

Cat. No. M27810

All AbMole products are for research use only, cannot be used for human consumption.

NecroX-7  Structure

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Quality Control & Documentation
Biological Activity

NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research.

Chemical Information
Molecular Weight 439.57
Formula C24H29N3O3S
CAS Number 1120332-55-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Subrata K Biswas. Atherosclerosis. NecroX-7 may appear as a new molecule to stabilize atherosclerotic plaques

[2] Mandy O J Grootaert, et al. Atherosclerosis. NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

[3] Hyo Kyun Chung, et al. Liver Int. The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation

[4] Hyun-Ju Kim, et al. Life Sci. A novel small molecule, NecroX-7, inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression

[5] Joonghoon Park, et al. Toxicol Appl Pharmacol. NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: NecroX-7  supplier, HMGB1, inhibitors, activators

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