About 12 results found for searched term "HMGB1" (0.172 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M22496 | Recombinant Mouse HMGB1 Protein (HEK293, hFc Tag) | Recombinant Proteins |
| High-mobility group box 1; HMG-1 | ||
| The recombinant mouse HMGB1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a calculated molecular mass of 53.3 kDa. High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family. HMGB1 is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death. | ||
| M22497 | Recombinant Human HMGB1 Protein (E. coli, C-His) | Recombinant Proteins |
| High Mobility Group Box-1; rHuHMGB1 | ||
| Human High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (a.a.) single chain polypeptide. | ||
| M41991 | HMGB1-IN-1 | HMGB1 |
| HMGB1-IN-1 inhibits the HMGB1/NF-κB/NLRP3 pathway and also exhibits strong NO inhibition in RAW264.7 cells with an IC50 value of 15.9 ± 0.6 μM. anti-inflammatory activity. | ||
| M42898 | HMGB1-IN-2 | HMGB1 |
| HMGB1-IN-2 is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC50 value of 20.2 μM in RAW264.7 cells. | ||
| M27810 | NecroX-7 | HMGB1 |
| NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research. | ||
| M30863 | Inflachromene | HMGB1 |
| Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders. | ||
| M38810 | Tricin 7-O-β-D-glucopyranoside | Apoptosis |
| Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1. | ||
| M45251 | SB17170 | HMGB1 |
| SB17170 is an HMGB1 modulator that can be used in studies related to solid tumors. | ||
| M45252 | SB1703 | HMGB1 |
| SB1703 is a high mobility group protein B1 (HMGB1) modulator for melanoma-related studies. | ||
| M45253 | AFX-2101 | HMGB1 |
| AFX-2101 is a high mobility group protein B1 (HMGB1) modulator for studies related to CNS trauma. | ||
| M45254 | 18-mer-HP | HMGB1 |
| 18-mer-HP is a high mobility group protein B1 (HMGB1) modulator that can be used in studies related to acute liver failure. | ||
| M45255 | HBP08 | HMGB1 |
| HBP08 is a high mobility group protein B1 (HMGB1) modulator that can be used in studies related to inflammation. | ||
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