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Inflachromene 

Cat. No. M30863

All AbMole products are for research use only, cannot be used for human consumption.

Inflachromene  Structure
Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 520  USD520 In stock
25mg USD 770  USD770 In stock
50mg USD 990  USD990 In stock
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Biological Activity

Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders.

Chemical Information
Molecular Weight 377.39
Formula C21H19N3O4
CAS Number 908568-01-4
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light, dry, sealed
References

[1] Shuai Teng, et al. Int Immunopharmacol. Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway

[2] Si-Jie Dai, et al. Acta Pharmacol Sin. Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation

[3] Sara Iachettini, et al. Autophagy. The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy

[4] Fuming Li, et al. Nat Cell Biol. FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

[5] Young Hun Kim, et al. J Cell Sci. Inflachromene inhibits autophagy through modulation of Beclin 1 activity

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Keywords: Inflachromene  supplier, HMGB1, inhibitors, activators

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