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Glycyrrhizic acid

Cat. No. M3909
Glycyrrhizic acid Structure
Synonym:

NSC 167409; Glycyrrhizin

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 74  USD74 In stock
200mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Glycyrrhizic acid shows anti-inflammatory, antiulcerous and antiallergic effects.glycyrrhizic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress. Glycyrrhizic acid would be a promising carrier for the oral delivery of PTX.

Chemical Information
Molecular Weight 822.94
Formula C42H62O16
CAS Number 1405-86-3
Solubility (25°C) DMSO ≥ 80 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yang FH, et al. Molecules. Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles.

[2] Akman T, et al. Inflammation. The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats.

[3] Fomina MK, et al. Ross Fiziol Zh Im I M Sechenova. [Effects of buspirone complex with glycyrrhizic acid on behavior of mice with anxious-depressive state].

[4] Wu CH, et al. J Agric Food Chem. Protective Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid against Cisplatin-Induced Nephrotoxicity in BALB/c Mice.

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Keywords: Glycyrrhizic acid, NSC 167409; Glycyrrhizin supplier, HMGB1, inhibitors, activators


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