Free shipping on all orders over $ 500

Motolimod (VTX-2337)

Cat. No. M5800

All AbMole products are for research use only, cannot be used for human consumption.

Motolimod (VTX-2337) Structure
Synonym:

VTX-2337; VTX-378

Size Price Availability Quantity
1mg USD 54  USD54 In stock
2mg USD 73  USD73 In stock
5mg USD 134  USD134 In stock
10mg USD 220  USD220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.

Chemical Information
Molecular Weight 458.6
Formula C28H34N4O2
CAS Number 926927-61-9
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dietsch GN, et al. Clin Cancer Res. Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337).

Related TLR Products
Pepinh-TRIF TFA

Pepinh-TRIF TFA blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction.

CAY10614

CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM.

TLR4-IN-C34-C2-COOH

TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

BNT411 

BNT411 is a selective TLR7 agonist that can induce the release of IFNa both in vivo and in vitro.

Rabeximod

Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation.

  Catalog
Abmole Inhibitor Catalog




Keywords: Motolimod (VTX-2337), VTX-2337; VTX-378 supplier, TLR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.