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MCP110

Cat. No. M20725
MCP110 Structure
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Biological Activity

MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.

Chemical Information
Molecular Weight 508.65
Formula C33H36N2O3
CAS Number 521310-51-0
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiang Li, et al. Gene. ALDH6A1 weakens the progression of colon cancer via modulating the RAS/RAF/MEK/ERK pathway in cancer cell lines

[2] Vladimir Khazak, et al. Enzymes. A two-hybrid approach to identify inhibitors of the RAS-RAF interaction

[3] Vanessa Gonzlez-Prez, et al. J Mol Signal. Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells

[4] Natalia Skobeleva, et al. Mol Cancer Ther. In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors

[5] Juran Kato-Stankiewicz, et al. Proc Natl Acad Sci U S A. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells

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Keywords: MCP110 supplier, Ras, inhibitors, activators

 
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