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Leriglitazone

Cat. No. M21176

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Leriglitazone Structure
Synonym:

Hydroxypioglitazone

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Quality Control & Documentation
Biological Activity

Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) is a PPARγ agonist that provides high transcriptional potency by stabilizing the PPARγ (AF-2) coactivator binding surface and enhancing coactivator binding capacity. Leriglitazone (Hydroxypioglitazone) binds to PPARγC (LBD) with a Ki value of 1.2 μM and induces PPARγ (LBD) transcriptional efficiency with an EC50 of 680 nM.

Chemical Information
Molecular Weight 372.44
Formula C19H20N2O4S
CAS Number 146062-44-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ludger Schls. Lancet Neurol. Leriglitazone: frustration and hope in adrenoleukodystrophy

[2] Paolo Santambrogio, et al. Pharmaceutics. PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes

[3] Massimo Pandolfo, et al. Neurol Genet. Efficacy and Safety of Leriglitazone in Patients With Friedreich Ataxia: A Phase 2 Double-Blind, Randomized Controlled Trial (FRAMES)

[4] Laura Rodrguez-Pascau, et al. Sci Transl Med. The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

[5] Laura Rodrguez-Pascau, et al. Neurobiol Dis. PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia

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  Catalog
Abmole Inhibitor Catalog




Keywords: Leriglitazone, Hydroxypioglitazone supplier, PPAR, inhibitors, activators

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