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KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death.
| Molecular Weight | 522.6 |
| Formula | C30H30N6O3 |
| CAS Number | 1369452-53-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GLUT Products |
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| GTPγS tetralithium
GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) acts as a component of lysis buffer. |
| SW157765
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. |
| GLUT inhibitor-1
GLUT inhibitor-1 is a potent and orally active glucose transporter protein (GLUT) inhibitor that targets GLUT1 and GLUT3 with IC50 values of 242 nM and 179 nM, respectively.GLUT inhibitor-1 can be used in cancer and autoimmune disease related studies. |
| SLC26A3-IN-3
SLC26A3-IN-3 is a SLC26A3 inhibitor (IC50: 40 nM). |
| MSNBA
MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes. |
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