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STF-31 is a selective glucose transporter GLUT1 inhibitor, with an IC50 of 1 μM. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
STF-31 is also a NAMPT inhibitor. In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT.
STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. STF-31 reduces the efferocytosis of wild type and SLC2A1-overexpressing LR73 cells.
STF-31 (10 mg/kg; i.p.) promotes accumulation of necrotic thymocytes after Dexamethasone-induced apoptosis in vivo.
| Molecular Weight | 423.53 |
| Formula | C23H25N3O3S |
| CAS Number | 724741-75-7 |
| Solubility (25°C) | DMSO 34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Adams DJ,et.al. ACS Chem Biol NAMPT is the cellular target of STF-31-like small-molecule probes.
| Related GLUT Products |
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GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) acts as a component of lysis buffer. |
| SW157765
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. |
| GLUT inhibitor-1
GLUT inhibitor-1 is a potent and orally active glucose transporter protein (GLUT) inhibitor that targets GLUT1 and GLUT3 with IC50 values of 242 nM and 179 nM, respectively.GLUT inhibitor-1 can be used in cancer and autoimmune disease related studies. |
| SLC26A3-IN-3
SLC26A3-IN-3 is a SLC26A3 inhibitor (IC50: 40 nM). |
| MSNBA
MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes. |
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