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K-Ras-IN-1

Cat. No. M20708
K-Ras-IN-1 Structure
Synonym:

MDK-3017

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

K-Ras-IN-1 inhibits K-Ras by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 207.29
Formula C11H13NOS
CAS Number 84783-01-7
Purity >99%
Solubility DMSO 41 mg/mL
Storage at -20°C
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Keywords: K-Ras-IN-1, MDK-3017 supplier, Ras, inhibitors

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