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Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. Guggulsterone is a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
| Molecular Weight | 312.45 |
| Formula | C21H28O2 |
| CAS Number | 95975-55-6 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | 4°C, protect from light |
[3] Ajaz A Bhat, et al. Nutr Metab (Lond). Potential therapeutic targets of Guggulsterone in cancer
[4] Takanori Yamada, et al. Adv Exp Med Biol. Guggulsterone and Its Role in Chronic Diseases
[5] Shishir Shishodia, et al. Curr Pharm Des. Guggulsterone for Chemoprevention of Cancer
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