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GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
| Molecular Weight | 419.95 |
| CAS Number | 2703752-81-0 |
| Solubility (25°C) | DMSO 10 mg/mL (ultrasonic and warming and heat to 60°C) Water 2.5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 2-8°C, dry, sealed |
| Related RIPK Products |
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RIP1/RIP3/MLKL activator 1 is a potent, blood-brain barrier permeable anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. |
| Oditrasertib
Oditrasertib is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value lower than 100 nM. |
| OD36 hydrochloride
OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. |
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RIPK1-IN-12 is a potent RIPK1 inhibitor. |
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DNL747 is an ASK1 and RIPK1 inhibitor for studies related to Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
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