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Tenofovir alafenamide, used as Tenofovir alafenamide fumarate (TAF), is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate, TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent.
Tenofovir alafenamide (GS-7340) showed concentration-dependent permeability through monolayers of caco-2 cells and dose-dependent oral bioavailability in dogs, increasing from 1.7% at 2 mg/kg to 24.7% at 20 mg/kg, suggesting saturable intestinal efflux transport.
| Molecular Weight | 476.47 |
| Formula | C21H29N6O5P |
| CAS Number | 379270-37-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL Water 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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