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Gemilukast

Cat. No. M27997

All AbMole products are for research use only, cannot be used for human consumption.

Gemilukast Structure
Synonym:

ONO-6950

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Quality Control & Documentation
Biological Activity

Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively.

Chemical Information
Molecular Weight 601.68
Formula C36H37F2NO5
CAS Number 1232861-58-3
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tomohiko Sekioka, et al. Prostaglandins Leukot Essent Fatty Acids. A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model

[2] G M Gauvreau, et al. Allergy. A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma

[3] Yasuo Yonetomi, et al. Eur J Pharmacol. Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma

[4] Satoshi Itadani, et al. J Med Chem. Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma

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Keywords: Gemilukast, ONO-6950 supplier, Leukotriene Receptor, inhibitors, activators

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