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Pranlukast is a selective cysteinyl leukotriene receptor antagonist. Pranlukast has an anti-inflammatory effect on bronchial eosinophilic infiltration. Pranlukast is now widely used in the treatment of asthma. Many clinical studies have indicated that pranlukast is well tolerated and is effective in reducing bronchial hyperresponsiveness and allergen-induced bronchoconstriction. The anti-asthmatic effect of pranlukast may be rendered not only by antileukotriene activity, but also by pharmacological activity including antieosinophilic effects.
| Molecular Weight | 481.5 |
| Formula | C27H23N5O4 |
| CAS Number | 103177-37-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Xiao-Yan Ye, et al. Effect of pranlukast on neonatal rats with periventricular leukomalacia
[3] Hoang Kim Tu Trinh, et al. Asthma pharmacotherapy: an update on leukotriene treatments
[5] Susan J Keam, et al. Pranlukast: a review of its use in the management of asthma
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