Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M8285 | Tryptanthrin | Tryptanthrin is a plant alkaloid with anti-inflammatory and anti cancer activities. |
| M8116 | CP-105,696 | CP-105,696 is an orally active, potent and selective leukotriene B4 receptor (LTB4R) antagonist (IC50 against [3H]LTB4 = 5. |
| M8110 | CP-424174 | CP-424174 is a cytokine release inhibitory compound (CRID) and also a reversible IL-1β inhibitor with an IC50 of 210 nM, which inhibits post-translational processing and secretion of IL-1β in human monocytes in the presence of LPS and ATP. |
| M7886 | LY255283 | LY255283 is a competitive leukotriene B4 receptor antagonist, with an IC50 of about 100 nM. |
| M5008 | Cyclopentyl Chloroformate | Mandelic acid derivatives and their use as thrombin inhibitors. |
| M3548 | Zafirlukast | Zafirlukast is a leukotriene receptor antagonist (LTRA) with IC50 of 0.6μM (IC50=7.0 µM for CYP2C9). |
| M3285 | Pranlukast | Pranlukast is a selective cysteinyl leukotriene receptor antagonist. |
| M41855 | Piriprost potassium | Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. |
| M41854 | LTB4 antagonist 3 | LTB4 antagonist 3 is a leukotriene B4 (LTB4) antagonist with an IC50 value of 477 nM. |
| M41853 | LTB4 antagonist 1 | LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC50 of 288 nM. |
| M41852 | LTB4 antagonist 2 | LTB4 antagonist 2, a carboxamide-acid compound, is an antagonist of leukotriene B4 (LTB4) with potentially anti-inflammatory activity. |
| M40988 | Tipelukast | Tipelukast is an orally bioavailable leukotriene receptor antagonist with anti-inflammatory activity for studies related to asthma and non-alcoholic steatohepatitis (NASH). |
| M38961 | Chamazulene | Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation. |
| M30170 | DW-1350 | DW-1350 is a LTB4 receptor antagonist. |
| M29955 | Amelubant | Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity. |
| M29132 | CP-195543 | CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration. |
| M28676 | Etalocib | Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis. |
| M27997 | Gemilukast | Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively. |
| M27912 | U-75302 | U-75302 is a potent inhibitor of leukotriene B4. U-75302 is a pyridine analogue. U-75302 has the potential for the research of inflammatory diseases. |
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