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Tryptanthrin is a plant alkaloid with anti-inflammatory and anti cancer activities. Tryptanthrin blocks leukotriene production in neutrophils and in whole blood assays, and in an in vivo rat pleurisy model. The compound also inhibits P-glycoprotein, and sensitizes resistant cancer cell lines to killing by cytotoxic agents.
| Molecular Weight | 248.24 |
| Formula | C15H8N2O2 |
| CAS Number | 13220-57-0 |
| Form | Solid |
| Solubility (25°C) | DMSO: 2 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Daniela Pinheiro, et al. Tryptanthrin derivatives as efficient singlet oxygen sensitizers
[4] Chi-Jan Lin, et al. Natural alkaloid tryptanthrin exhibits novel anticryptococcal activity
[5] Jie Wu, et al. (Nitrato-κO,O')bis-(tryptanthrin-κN)silver(I)
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