Free shipping on all orders over $ 500

Tryptanthrin

Cat. No. M8285
Tryptanthrin Structure
Size Price Availability Quantity
10mg USD 85  USD85 In stock
50mg USD 255  USD255 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Tryptanthrin is a plant alkaloid with anti-inflammatory and anti cancer activities. Tryptanthrin blocks leukotriene production in neutrophils and in whole blood assays, and in an in vivo rat pleurisy model. The compound also inhibits P-glycoprotein, and sensitizes resistant cancer cell lines to killing by cytotoxic agents.

Chemical Information
Molecular Weight 248.24
Formula C15H8N2O2
CAS Number 13220-57-0
Form Solid
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daniela Pinheiro, et al. Tryptanthrin derivatives as efficient singlet oxygen sensitizers

[2] Xiujin Shi, et al. Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway

[3] Qingfang Zeng, et al. Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment

[4] Chi-Jan Lin, et al. Natural alkaloid tryptanthrin exhibits novel anticryptococcal activity

[5] Jie Wu, et al. (Nitrato-κO,O')bis-(tryptanthrin-κN)silver(I)

Related Leukotriene Receptor Products
Piriprost potassium

Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis.

LTB4 antagonist 3

LTB4 antagonist 3 is a leukotriene B4 (LTB4) antagonist with an IC50 value of 477 nM.

LTB4 antagonist 1

LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC50 of 288 nM.

LTB4 antagonist 2

LTB4 antagonist 2, a carboxamide-acid compound, is an antagonist of leukotriene B4 (LTB4) with potentially anti-inflammatory activity.

Tipelukast

Tipelukast is an orally bioavailable leukotriene receptor antagonist with anti-inflammatory activity for studies related to asthma and non-alcoholic steatohepatitis (NASH).

  Catalog
Abmole Inhibitor Catalog




Keywords: Tryptanthrin supplier, Leukotriene Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.