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GCA-186 

Cat. No. M28543

All AbMole products are for research use only, cannot be used for human consumption.

GCA-186  Structure

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Quality Control & Documentation
Biological Activity

GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively.

Chemical Information
Molecular Weight 330.42
Formula C19H26N2O3
CAS Number 149950-61-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Nasser R El-Brollosy, et al. Arch Pharm (Weinheim). Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186

[2] Esben R Sørensen, et al. Arch Pharm (Weinheim). Synthesis of 6-(3,5-dichlorobenzyl) derivatives as isosteric analogues of the HIV drug 6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil (GCA-186)

[3] A L Hopkins, et al. J Med Chem. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants

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Keywords: GCA-186  supplier, HIV Protease, inhibitors, activators

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