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RX-3117

Cat. No. M22390

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RX-3117 Structure
Synonym:

Fluorocyclopentenylcytosine; TV-1360

Size Price Availability Quantity
2mg USD 285  USD285 In stock
5mg USD 420  USD420 In stock
10mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

RX-3117 (TV-1360) is a potent and orally active anticancer and antimetabolite agent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis.

Chemical Information
Molecular Weight 257.22
Formula C10H12FN3O4
CAS Number 865838-26-2
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Beatrice Balboni, et al. Expert Opin Investig Drugs. RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

[2] Dzjemma Sarkisjan, et al. PLoS One. The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2

[3] Mi Young Yang, et al. Anticancer Res. A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine

[4] Godefridus J Peters. Nucleosides Nucleotides Nucleic Acids. Novel developments in the use of antimetabolites

[5] Godefridus J Peters, et al. Invest New Drugs. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)

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Keywords: RX-3117, Fluorocyclopentenylcytosine; TV-1360 supplier, Apoptosis, inhibitors, activators

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