Filipin is a 28-member cyclopentaene macrolide antifungal antibiotic produced by S. avermitilis and S. Miharaensis in 2012. Filipin can interact with phytosterol to change the membrane structure. Filipin III is the main component of Filipin.
| Molecular Weight | 654.8 |
| Formula | C35H58O11 |
| CAS Number | 11078-21-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] C E Blanchard, et al. Acta Anat (Basel). Filipin-sterol complexes in disrupted myelin in the rat
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