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Fluuridine is a nucleoside antiviral compound. The compound showed significant mitochondrial toxicity. Fialuridine is also a DNA-directed DNA polymerase inhibitor that may be used to treat HBV infection and has potent activity against hepatitis B virus in vivo and in vitro. FIAU blocks DNA synthesis of human cytomegalovirus, hepatitis B and herpes simplex viruses.
| Molecular Weight | 372.09 |
| Formula | C9H10FIN2O5 |
| CAS Number | 69123-98-4 |
| Solubility (25°C) | DMSO 4 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Nucleoside Analogues
[3] No authors listed. Review of the Fialuridine (FIAU) Clinical Trials
[4] P Honkoop, et al. Mitochondrial injury. Lessons from the fialuridine trial
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