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Fialuridine

Cat. No. M8400
Fialuridine Structure
Synonym:

FIAU; DRG-0098

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 135  USD135 In stock
25mg USD 290  USD290 In stock
50mg USD 460  USD460 In stock
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Quality Control & Documentation
Biological Activity

Fluuridine is a nucleoside antiviral compound. The compound showed significant mitochondrial toxicity. Fialuridine is also a DNA-directed DNA polymerase inhibitor that may be used to treat HBV infection and has potent activity against hepatitis B virus in vivo and in vitro. FIAU blocks DNA synthesis of human cytomegalovirus, hepatitis B and herpes simplex viruses.

Chemical Information
Molecular Weight 372.09
Formula C9H10FIN2O5
CAS Number 69123-98-4
Solubility (25°C) DMSO 4 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Nucleoside Analogues

[2] Delilah F G Hendriks, et al. Mechanisms of chronic fialuridine hepatotoxicity as revealed in primary human hepatocyte spheroids

[3] No authors listed. Review of the Fialuridine (FIAU) Clinical Trials

[4] P Honkoop, et al. Mitochondrial injury. Lessons from the fialuridine trial

[5] R Schmid. Fialuridine toxicity

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Keywords: Fialuridine, FIAU; DRG-0098 supplier, DNA/RNA Synthesis, inhibitors, activators


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