Free shipping on all orders over $ 500

Fangchinoline

Cat. No. M4515
Fangchinoline Structure
Size Price Availability Quantity
5mg USD 45  USD45 In stock
10mg USD 70  USD70 In stock
20mg USD 100  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

Chemical Information
Molecular Weight 608.72
Formula C37H40N2O6
CAS Number 33889-68-8
Solubility (25°C) 100 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Keting Bao, et al. Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

[2] Lin Zhou, et al. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling

[3] Wenjun Zhu, et al. Fangchinoline Promotes Autophagy and Inhibits Apoptosis in Osteoporotic Rats

[4] Lu Shan, et al. Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats

[5] Yingsong Jiang, et al. Fangchinoline Protects Against Renal Injury in Diabetic Nephropathy by Modulating the MAPK Signaling Pathway

Related HIV Protease Products
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease.

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease.

HIV-1, HIV-2 Protease Substrate

HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease.

HIV Protease Substrate IV

HIV Protease Substrate IV is a substrate of HIV protease.

Herpes virus inhibitor 2

Herpes virus inhibitor 2 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure.

  Catalog
Abmole Inhibitor Catalog




Keywords: Fangchinoline supplier, HIV Protease, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.