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Eicosapentaenoic acid ethyl ester

Cat. No. M20994
Eicosapentaenoic acid ethyl ester Structure
Synonym:

AMR101, EPA ethyl ester, Ethyl eicosapentaenoate

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Quality Control & Documentation
Biological Activity

Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.

Chemical Information
Molecular Weight 330.5
Formula C22H34O2
CAS Number 86227-47-6
Solubility (25°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M John Chapman, et al. Pharmacol Ther. Reducing residual cardiovascular risk in Europe: Therapeutic implications of European medicines agency approval of icosapent ethyl/eicosapentaenoic acid

[2] Yawei Fu, et al. Mediators Inflamm. Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

[3] Klaus G Parhofer, et al. Dtsch Arztebl Int. The Diagnosis and Treatment of Hypertriglyceridemia

[4] Deepak L Bhatt, et al. N Engl J Med. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

[5] James Backes, et al. Lipids Health Dis. The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia

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Keywords: Eicosapentaenoic acid ethyl ester, AMR101, EPA ethyl ester, Ethyl eicosapentaenoate supplier, FAS, inhibitors, activators

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