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EB-3D

Cat. No. M14836

All AbMole products are for research use only, cannot be used for human consumption.

EB-3D Structure

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Biological Activity

EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity.

Chemical Information
Molecular Weight 644.44
CAS Number 1839150-63-8
Solubility (25°C) DMSO 50 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Huawei Qu, et al. Fractal Design Boosts Extrusion-Based 3D Printing of Bone-Mimicking Radial-Gradient Scaffolds

[2] Alberto Sola-Leyva, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells

[3] Elena Mariotto, et al. Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

[4] Elena Mariotto, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells

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Keywords: EB-3D supplier, AMPK, inhibitors, activators

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