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Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication. Doxorubicin inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy.
| Molecular Weight | 543.52 |
| Formula | C27H29NO11 |
| CAS Number | 23214-92-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[3] Sangeeta Rivankar. J Cancer Res Ther. An overview of doxorubicin formulations in cancer therapy
[4] Cristina Carvalho, et al. Curr Med Chem. Doxorubicin: the good, the bad and the ugly effect
[5] P A Speth, et al. Clin Pharmacokinet. Clinical pharmacokinetics of doxorubicin
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
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