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Dac51 is an effective FTO inhibitor with an IC50 of 0.4 μM against FTO demethylation.
Orthop Surg. 2024 May;16(5):1175-1186.
Mechanism of Fat Mass and Obesity-Related Gene-Mediated Heme Oxygenase-1 m6A Modification in the Recovery of Neurological Function in Mice with Spinal Cord Injury
Dac51 purchased from AbMole
| Molecular Weight | 505.27 |
| Formula | C20H17Cl2F3N4O4 |
| CAS Number | 2243944-92-3 (free base) |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FTO Products |
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| FTO-IN-1 TFA
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor, with an IC50 of <1 μM. |
| Ethyl LipotF
Ethyl LipotF is a selective FTO inhibitor that significant increases modified N6-methyladenosine (m6A) levels in HeLa cells in a concentration-dependent manner. |
| ZLD115
ZLD115 is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). |
| Meclofenamic acid sodium hydrate
Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively. |
| Meclofenamic acid
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively. |
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