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Cyclotriazadisulfonamide

Cat. No. M28929

All AbMole products are for research use only, cannot be used for human consumption.

Cyclotriazadisulfonamide Structure
Synonym:

CADA

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Quality Control & Documentation
Biological Activity

Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor.

Chemical Information
Molecular Weight 581.79
Formula C31H39N3O4S2
CAS Number 182316-44-5
Form Solid
Solubility (25°C) DMSO 33.33 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Eva Pauwels, et al. Int J Mol Sci. Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide

[2] Karoline Berger, et al. J Med Chem. Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds

[3] Elisa Claeys, et al. Front Immunol. Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes

[4] Victor Van Puyenbroeck, et al. Traffic. Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide

[5] Violeta G Demillo, et al. J Med Chem. Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents

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Keywords: Cyclotriazadisulfonamide, CADA supplier, HIV Protease, inhibitors, activators

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