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Cyclic-di-GMP diammonium

Cat. No. M14122
Cyclic-di-GMP diammonium Structure
Synonym:

c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium

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Biological Activity

Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species.

Chemical Information
Molecular Weight 724.47
CAS Number 609343-82-0
Solubility (25°C) Water 50 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Cyclic-di-GMP diammonium, c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium supplier, STING, inhibitors, activators


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