CY3 (Sulfo-Cyanine3) is a widely used, orange fluorescent marker for proteins and nucleic acids (λex=554, λem=568).
| Molecular Weight | 630.77 |
| Formula | C31H38N2O8S2 |
| CAS Number | 146368-13-0 |
| Form | Solid |
| Solubility (25°C) | DMF 10 mg/mL DMSO 15 mg/mL Ethanol 1 mg/mL |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Itallia V Pacentine, et al. Sci Rep. Cy3-ATP labeling of unfixed, permeabilized mouse hair cells
[4] Hayato Kawai, et al. Chemistry. Perylene-Cy3 FRET System to Analyze Photoactive DNA Structures
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