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Chamazulene

Cat. No. M38961
Chamazulene Structure
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Biological Activity

Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation.

Chemical Information
Molecular Weight 184.28
Formula C14H16
CAS Number 529-05-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Amina El Mihyaoui et al. Life (Basel). Chamomile ( Matricaria chamomilla L.): A Review of Ethnomedicinal Use, Phytochemistry and Pharmacological Uses

[2] Ding Ma et al. Biosci Biotechnol Biochem. Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβ pathway in in-vitro and in-vivo models

[3] Diane L McKay et al. Phytother Res. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

[4] E PENUNURI et al. J Pharm Sci. Chamazulene from Artemesia caruthii

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Keywords: Chamazulene supplier, Leukotriene Receptor, inhibitors, activators

 
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