Free shipping on all orders over $ 500

Brecanavir

Cat. No. M29893
Brecanavir Structure
Synonym:

GW640385

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Brecanavir (GW640385) is a novel, potent HIV protease inhibitor.

Chemical Information
Molecular Weight 703.82
Formula C33H41N3O10S2
CAS Number 313682-08-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Emile J Velthuisen, et al. Eur J Med Chem. Synthesis and pharmacokinetic profile of highly deuterated brecanavir analogs

[2] Richard Hazen, et al. Antimicrob Agents Chemother. In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV

[3] No authors listed. AIDS Patient Care STDS. Brecanavir's hopes dashed

[4] Y Sunila Reddy, et al. Antimicrob Agents Chemother. Safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus type 1 protease inhibitor, following repeat administration with and without ritonavir in healthy adult subjects

[5] Susan L Ford, et al. Antimicrob Agents Chemother. Single-dose safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus protease inhibitor

Related HIV Protease Products
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease.
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease.
HIV-1, HIV-2 Protease Substrate

HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease.
HIV Protease Substrate IV

HIV Protease Substrate IV is a substrate of HIV protease.
Herpes virus inhibitor 2

Herpes virus inhibitor 2 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure.
  Catalog
Abmole Inhibitor Catalog




Keywords: Brecanavir, GW640385 supplier, HIV Protease, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.