AZD4625 is a highly potent, selective, covalent and metabotropic inhibitor of the mutant GTPase KRASG12C. AZD4625 has high oral bioavailability. It is being developed to study advanced solid malignancies.
| Molecular Weight | 486.90 |
| Formula | C24H21ClF2N4O3 |
| Solubility (25°C) | N/A |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Ras Products |
|---|
| ACBI3
ACBI3 is a selective and potent pan-KRAS degrader. |
| MK-1084
MK-1084 is a KRAS G12C inhibitor that can be used in studies related to solid tumors. |
| CFL-120
CFL-120 is a potent KRasG12C inhibitor. |
| CFL-137
CFL-137 is a potent KRasG12C inhibitor. |
| Oligomycin D
Oligomycin D (Rutamycin A) is an antibiotic. |
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