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AZ-23

Cat. No. M14579
AZ-23 Structure
Synonym:

AZ23; AZ 23

Size Price Availability
5mg USD 220  USD220 1-2 Weeks
10mg USD 360  USD360 1-2 Weeks
25mg USD 760  USD760 1-2 Weeks
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Quality Control & Documentation
Biological Activity

AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.

Chemical Information
Molecular Weight 391.83
CAS Number 915720-21-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xu Chu, et al. Blocking Cancer-Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain

[2] Suning Chen, et al. A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report

[3] Tao Wang, et al. Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors

[4] Kenneth Thress, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

[5] A Zanella, et al. Avian infectious bronchitis: characterization of new isolates from Italy

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZ-23, AZ23; AZ 23 supplier, Trk, inhibitors, activators

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