Free shipping on all orders over $ 500

AZ-23

Cat. No. M14579
AZ-23 Structure
Synonym:

AZ23; AZ 23

Size Price Availability
5mg USD 220  USD220 1-2 Weeks
10mg USD 360  USD360 1-2 Weeks
25mg USD 760  USD760 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 391.83
Formula
CAS Number 915720-21-7
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Xu Chu, et al. Blocking Cancer-Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain

[2] Suning Chen, et al. A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report

[3] Tao Wang, et al. Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors

[4] Kenneth Thress, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

[5] A Zanella, et al. Avian infectious bronchitis: characterization of new isolates from Italy

Related Trk Products
MRTX849 ethoxypropanoic acid

LC-2 is a potent, first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50, between 0.25 and 0.76 μM).

Tavilermide

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

Cyclotraxin B acetate

Cyclotraxin B acetate, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF.

Selitrectinib (LOXO-195)

Selitrectinib (LOXO-195) is a potent and selective, next-generation TRK inhibitor, with IC50 values of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC, respectively.

PF-06733804

PF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: AZ-23, AZ23; AZ 23 supplier, Trk, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.