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AZ-23

Cat. No. M14579

All AbMole products are for research use only, cannot be used for human consumption.

AZ-23 Structure
Synonym:

AZ23; AZ 23

Size Price Availability
5mg USD 220  USD220 1-2 Weeks
10mg USD 360  USD360 1-2 Weeks
25mg USD 760  USD760 1-2 Weeks
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Quality Control & Documentation
Biological Activity

AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.

Chemical Information
Molecular Weight 391.83
CAS Number 915720-21-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xu Chu, et al. Blocking Cancer-Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain

[2] Suning Chen, et al. A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report

[3] Tao Wang, et al. Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors

[4] Kenneth Thress, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

[5] A Zanella, et al. Avian infectious bronchitis: characterization of new isolates from Italy

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZ-23, AZ23; AZ 23 supplier, Trk, inhibitors, activators

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