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Protein kinase inhibitor 4 is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively).
| Molecular Weight | 526.56 |
| Formula | C25H24F2N6O3S |
| CAS Number | 2278205-04-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Shom Goel et al. Nat Rev Cancer. Targeting CDK4 and CDK6 in cancer
[5] Robert Roskoski Jr. Pharmacol Res. The ErbB/HER family of protein-tyrosine kinases and cancer
| Related Trk Products |
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| Cyclotraxin B
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. |
| Gambogic amide
Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK. |
| TRK-IN-22
TRK-IN-22 is a TRK inhibitor. |
| TrkB-IN-1
TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties. |
| Type II TRK inhibitor 1
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. |
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