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 About 30 results found for searched term "Trk" (0.025 seconds)

Cat.No.  Name Information
M2192 BMS-754807 Bms-754807 is a potent igf-1r /InsR reversible inhibitor with an IC50 of 1.8 nM/1.7 nM and also inhibits the activity of Met, RON, TrkA, TrkB, AurA and AurB with an IC50 value of 6,44,7,4, respectively. At 9 and 25 nM, it has almost no inhibitory activity against Flt3, Lck, MK2, PKA and PKC.
M2585 GNF-5837 GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively.
M2744 GW441756 GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.
M2790 K252a K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
M3221 PF-03814735 PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1.
M3515 MK-2461 MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB.
M3516 MK-5108 MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity.
M4452 Echinacoside Echinacoside is a phenylethanol compound isolated from Cistanche salsa that effectively inhibits the Wnt/β-catenin signaling pathway. Echinacoside plays a neuroprotective role by activating Trk receptors and their downstream signaling pathways. Echinacoside also has significant anti-osteoporosis activity.
M5074 ANA-12 ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.
M5304 7,8-Dihydroxyflavone 7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).
M5613 Entrectinib (RXDX-101) Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM.
M6151 Larotrectinib (LOXO-101) Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
M6186 Repotrectinib (TPX-0005) Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively.
M6211 LOXO-101 sulfate LOXO-101 sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).
M6795 HIOC HIOC is a selective TrkB receptor agonist; neuroprotectant.
M6904 Lestaurtinib Lestaurtinib is a jAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB.
M7118 PF 06273340 PF 06273340 is a potent and selective pan-Trk inhibitor; peripherally restricted.
M7537 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.
M8104 PF-06683324 PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor.
M8105 PF-06737007 PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor.
M8106 PF-06733804 PF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor.
M9107 Selitrectinib (LOXO-195) Selitrectinib (LOXO-195) is a potent and selective, next-generation TRK inhibitor, with IC50 values of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC, respectively.
M9626 Sitravatinib Sitravatinib (MGCD516) is an orally active receptor tyrosine kinase (RTK) inhibitor. Inhibition of Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, and TRKB at 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, respectively. 29 nM, 5 nM and 9 nM. Sitravatinib alone has a potent antitumor effect and enhances pD-1 blockade activity by promoting the antitumor immune microenvironment.
M10484 Nalfurafine hydrochloride Nalfurafine hydrochloride (TRK-820 hydrochloride) is a potent selective and orally active kappa opioid receptor (KOR) agonist.
M10736 CH7057288 CH7057288 is a potent selective TRK inhibitor.
M10936 Taletrectinib Taletrectinib (DS-6051b) is a potent orally active next-generation selective ROS1/NTRK inhibitor. Taletrectinib is 0.207, 0.622, 2.28, and 0.98 nM, respectively IC50 It has a strong inhibitory effect on recombinant ROS1, NTRK1, NTRK2 and NTRK3. Taletrectinib also inhibits ROS1 G2032R and other ANTI-Crizotinib ROS1 mutants.
M11011 LM22B-10 LM22B-10 is a TrkB/TrkC neurotrophic factor receptor activator that induces activation of TrkB, TrkC, AKT and ERK in vitro.
M11193 BDNF, Human (CHO) BDNF protein, Human (CHO), is a neurotrophic factor that binds to TrkB receptors and regulates neural development, including neuronal survival, differentiation, and synaptic plasticity.
M13399 CE-245677 CE-245677 is a potent and reversible inhibitor of Tie2 and TrkA/B, with IC50 values of 4.7 and 1 nM, respectively, in the cellular system.
M14392 N-Acetyl-5-hydroxytryptamine N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.

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