About 30 results found for searched term "Trk" (0.025 seconds)
Cat.No. | Name | Information |
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M2192 | BMS-754807 | Bms-754807 is a potent igf-1r /InsR reversible inhibitor with an IC50 of 1.8 nM/1.7 nM and also inhibits the activity of Met, RON, TrkA, TrkB, AurA and AurB with an IC50 value of 6,44,7,4, respectively. At 9 and 25 nM, it has almost no inhibitory activity against Flt3, Lck, MK2, PKA and PKC. |
M2585 | GNF-5837 | GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively. |
M2744 | GW441756 | GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. |
M2790 | K252a | K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. |
M3221 | PF-03814735 | PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. |
M3515 | MK-2461 | MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. |
M3516 | MK-5108 | MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. |
M4452 | Echinacoside | Echinacoside is a phenylethanol compound isolated from Cistanche salsa that effectively inhibits the Wnt/β-catenin signaling pathway. Echinacoside plays a neuroprotective role by activating Trk receptors and their downstream signaling pathways. Echinacoside also has significant anti-osteoporosis activity. |
M5074 | ANA-12 | ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively. |
M5304 | 7,8-Dihydroxyflavone | 7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). |
M5613 | Entrectinib (RXDX-101) | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. |
M6151 | Larotrectinib (LOXO-101) | Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. |
M6186 | Repotrectinib (TPX-0005) | Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively. |
M6211 | LOXO-101 sulfate | LOXO-101 sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). |
M6795 | HIOC | HIOC is a selective TrkB receptor agonist; neuroprotectant. |
M6904 | Lestaurtinib | Lestaurtinib is a jAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB. |
M7118 | PF 06273340 | PF 06273340 is a potent and selective pan-Trk inhibitor; peripherally restricted. |
M7537 | SNS-314 | SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. |
M8104 | PF-06683324 | PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor. |
M8105 | PF-06737007 | PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor. |
M8106 | PF-06733804 | PF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor. |
M9107 | Selitrectinib (LOXO-195) | Selitrectinib (LOXO-195) is a potent and selective, next-generation TRK inhibitor, with IC50 values of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC, respectively. |
M9626 | Sitravatinib | Sitravatinib (MGCD516) is an orally active receptor tyrosine kinase (RTK) inhibitor. Inhibition of Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, and TRKB at 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, respectively. 29 nM, 5 nM and 9 nM. Sitravatinib alone has a potent antitumor effect and enhances pD-1 blockade activity by promoting the antitumor immune microenvironment. |
M10484 | Nalfurafine hydrochloride | Nalfurafine hydrochloride (TRK-820 hydrochloride) is a potent selective and orally active kappa opioid receptor (KOR) agonist. |
M10736 | CH7057288 | CH7057288 is a potent selective TRK inhibitor. |
M10936 | Taletrectinib | Taletrectinib (DS-6051b) is a potent orally active next-generation selective ROS1/NTRK inhibitor. Taletrectinib is 0.207, 0.622, 2.28, and 0.98 nM, respectively IC50 It has a strong inhibitory effect on recombinant ROS1, NTRK1, NTRK2 and NTRK3. Taletrectinib also inhibits ROS1 G2032R and other ANTI-Crizotinib ROS1 mutants. |
M11011 | LM22B-10 | LM22B-10 is a TrkB/TrkC neurotrophic factor receptor activator that induces activation of TrkB, TrkC, AKT and ERK in vitro. |
M11193 | BDNF, Human (CHO) | BDNF protein, Human (CHO), is a neurotrophic factor that binds to TrkB receptors and regulates neural development, including neuronal survival, differentiation, and synaptic plasticity. |
M13399 | CE-245677 | CE-245677 is a potent and reversible inhibitor of Tie2 and TrkA/B, with IC50 values of 4.7 and 1 nM, respectively, in the cellular system. |
M14392 | N-Acetyl-5-hydroxytryptamine | N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor. |
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