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Trk Trk receptor

Cat.No.  Name Information
M6151 Larotrectinib (LOXO-101) Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
M14580 Cyclotraxin B acetate Cyclotraxin B acetate, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF.
M14579 AZ-23 AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
M11011 LM22B-10 LM22B-10 is a TrkB/TrkC neurotrophic factor receptor activator that induces activation of TrkB, TrkC, AKT and ERK in vitro.
M10936 Taletrectinib Taletrectinib (DS-6051b) is a potent orally active next-generation selective ROS1/NTRK inhibitor. Taletrectinib is 0.207, 0.622, 2.28, and 0.98 nM, respectively IC50 It has a strong inhibitory effect on recombinant ROS1, NTRK1, NTRK2 and NTRK3. Taletrectinib also inhibits ROS1 G2032R and other ANTI-Crizotinib ROS1 mutants.
M10736 CH7057288 CH7057288 is a potent selective TRK inhibitor.
M9107 Selitrectinib (LOXO-195) Selitrectinib (LOXO-195) is a potent and selective, next-generation TRK inhibitor, with IC50 values of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC, respectively.
M6910 LM22A-4 LM22A-4 is a specific agonist of tyrosine kinase receptor B, used for neurological disease research.
M6211 LOXO-101 sulfate LOXO-101 sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).
M5304 7,8-Dihydroxyflavone 7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).
M5074 ANA-12 ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.
M2744 GW441756 GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.
M2585 GNF-5837 GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively.
M54511 Cyclotraxin B Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF.
M49739 Gambogic amide Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK.
M43539 Protein kinase inhibitor 4 Protein kinase inhibitor 4 is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively).
M42719 TRK-IN-22 TRK-IN-22 is a TRK inhibitor.
M42718 TrkB-IN-1 TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties.
M42717 Type II TRK inhibitor 1 Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type.
M42716 TRK-IN-23 TRK-IN-23 is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively.

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