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GW441756

Cat. No. M2744
GW441756 Structure
Size Price Availability Quantity
10mg USD 90  USD90 In stock
50mg USD 380  USD380 In stock
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Quality Control
Biological Activity

GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 275.3
Formula C17H13N3O
CAS Number 504433-23-2
Purity >98%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] Marzia Di Donato, et al. Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells

[2] Aditi A Bapat, et al. Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells

[3] Surabhi Shukla, et al. Mechanism for neurotropic action of vorinostat, a pan histone deacetylase inhibitor

[4] Tada-aki Kudo, et al. Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation

[5] Eun Joo Jung, et al. Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells

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Keywords: GW441756 supplier, Trk, inhibitors

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