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GW441756

Cat. No. M2744
GW441756 Structure
Size Price Availability Quantity
10mg USD 90  USD90 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.

Chemical Information
Molecular Weight 275.3
Formula C17H13N3O
CAS Number 504433-23-2
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marzia Di Donato, et al. Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells

[2] Aditi A Bapat, et al. Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells

[3] Surabhi Shukla, et al. Mechanism for neurotropic action of vorinostat, a pan histone deacetylase inhibitor

[4] Tada-aki Kudo, et al. Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation

[5] Eun Joo Jung, et al. Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells

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  Catalog
Abmole Inhibitor Catalog




Keywords: GW441756 supplier, Trk, inhibitors, activators

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