About 22 results found for searched term "AZ-23" (0.21 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2422 | AZD5423 | GCR |
| AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. | ||
| M14579 | AZ-23 | Trk |
| AZ23; AZ 23 | ||
| AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. | ||
| M25432 | NAZ2329 | Phosphatase |
| NAZ2329 is the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. | ||
| M45125 | AZD-8233 | PCSK9 |
| AZD-8233 is an orally active, antisense oligonucleotide (ASO) targeting PCSK9 that targets and inhibits the translation and protein synthesis of PCSK9 mRNA in hepatocytes and reduces circulating LDL-C levels. It can be used in studies related to hypercholesterolemia. | ||
| M1657 | Atazanavir Sulfate | HIV Protease |
| BMS-232632, Reyataz, CGP-73547 | ||
| Atazanavir sulfate (BMS-232632, Reyataz) is an azapeptide inhibitor of HIV-1 protease. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M2437 | Bazedoxifene hydrochloride | Estrogen Receptor |
| TSE-424 | ||
| Bazedoxifene hydrochloride is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM. | ||
| M3251 | Bazedoxifene Acetate | Estrogen Receptor |
| TSE 424; WAY-TES 424 | ||
| Bazedoxifene Acetate is a third generation, oral and nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. | ||
| M5427 | Atazanavir | HIV Protease |
| BMS-232632; Latazanavir; Zrivada; Reyataz | ||
| Atazanavir (BMS-232632) is an azapeptide and HIV-protease inhibitor. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M8392 | Tirapazamine | Apoptosis |
| SR259075; SR4233; Win59075; SML 0552; Tirazone; TPZ | ||
| Tirapazamine (TPZ，SR-4233, WIN 59075) is the first hypoxia-activated prodrug. Tirapazamine kills hypoxic cells by inducing chromosome aberrations and DNA double-strand breaks. Tirapazamine induced cell cycle arrest and apoptosis, and down-regulated HIF-1α, CA-IX and VEGF expression. | ||
| M10143 | AZ3451 | PAR |
| AZ-3451 | ||
| AZ3451 is a potent PAR2 (protease-activated receptor-2) antagonist with IC50 of 23 nM, which plays a part in inflammation response, apoptosis, autophagy and cellular senescence during Osteoarthritis (OA). | ||
| M10339 | Fexinidazole | Anti-infection |
| Hoe-239 | ||
| Fexinidazole (also known as Hoe-239) is an orally active, potent antiparasitic agent. | ||
| M10372 | Vazegepant hydrochloride | CGRP Receptor |
| Zavegepant, BHV-3500 hydrochloride | ||
| Vazegepant (BHV-3500) hydrochloride is a first-in-class, high affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride may be useful in the effective treatment of lung inflammation associated with COVID-19. | ||
| M11173 | PC945 | Others |
| PC945 is a potent antifungal triazole drug that is resistant to a variety of sensitive and resistant strains of Aspergillus fumigatus. PC945 is a potent, tightly bound inhibitor of aspergilloxine 14α-demethylase (CYP51A/CYP51B) activity.IC50s are 0.23 μM and 0.22 μM, respectively. | ||
| M14265 | Pantoprazole sodium hydrate | Proton Pump |
| BY1023 sodium hydrate; SKF96022 sodium hydrate | ||
| Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium hydrate is also a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. | ||
| M21784 | AZ1495 | IRAK |
| AZ1495 is a weak base and orally active, potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with a Kd value of 0.0007 μM.AZ1495 has good physicochemical and kinase selectivity for IRAK4 and IRAK1, with IC50 values of 0.005 μM and 0.023 μM, respectively.AZ1495 is used in studies of diffuse large B-cell lymphoma (DLBCL). | ||
| M22417 | Bazedoxifene | Estrogen Receptor |
| TSE-424 | ||
| Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer. | ||
| M25146 | Mazorelvimab | Anti-infection |
| SYN023 | ||
| Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies. | ||
| M27684 | Lazabemide hydrochloride | Monoamine Oxidase |
| Ro 19-6327 hydrochloride | ||
| Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease. | ||
| M29164 | TBI-223 | Antibiotic |
| TBI-223 is an orally bioavailable oxazolidinone antibiotic and an antimicrobial. TBI-223 shows activity against Mycobacterium tuberculosis (Mtb). | ||
| M30377 | HJ-PI01 | Pim |
| 10-Acetylphenoxazine | ||
| HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research. | ||
| M40875 | Brazikumab | IL Receptor/Related |
| AMG 139; MEDI2070 | ||
| Brazikumab is a human IgG2 monoclonal antibody targeting IL-23 that selectively binds to the p19 subunit of IL-23 and has a KD value of 0.138 nM against human IL-23 for Crohn's disease (CD). | ||
| M45286 | MRT00033659 | Casein Kinase |
| MRT00033659 is a pyrazolopyridine analog that induces p53 pathway activation. It is also a potent broad-spectrum kinase inhibitor that inhibits CK1 (for CK1δ: IC50=0.9 µM) and CHK1 (IC50=0.23 µM). | ||
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